Figure 1.

Required level of evidence needed for implementation of different types of alternative dosing regimens. The y-axis represents cumulative pharmacokinetic exposure. Dotted horizontal lines represent the clinical no-effect boundaries for exposure. On the x-axis different alternative dosing regimens are represented. These are categorized into three subtypes: leading to equivalent exposure (pink), lower or shorter exposure (green), or higher exposure (gray). Top bars indicate the proposed evidence required for implementation. The dots represent the relevant pharmacokinetic exposure parameter of alternative dosing regimens, chosen at random to illustrate the examples.