Table 2.
Cytotoxicity assays of studied DESs.
| Entry | DES components | Assay | Cell lines | Results | Ref |
|---|---|---|---|---|---|
| 1 | ChCl:MA ChCl:CA ChCl:LA ChCl:Fru ChCl:Xyl ChCl:Man |
MTT | CCO | ChCl-based DESs are less toxic than ILs. | [71] |
| 2 | ChCl:gly ChCl:Glc ChCl:OA |
MTT | CCO, MCF-7 | ChCl: gly and ChCl:Glc EC50 > 10mM ChCl:OA EC50 1.64 ± 0.14mM for CCO and 4.19 ± 0.19 mM for MCF-7 |
[67] |
| 3 | ChCl:gly ChCl:U ChCl:G ChCl:TEG |
MTT | MCF-7, A375, OKF6, HT29, H413, PC3, HepG2 | Increased values of IC50 were obtained for ChCl:TEG, ChCl:gly, ChCl:EG, ChCl:U with OKF6, MCF-7, A375, HT29 and H413, respectively | [72] |
| 4 | ChCl:Glc ChCl:Frc ChCl:Suc ChCl:gly ChCl:MA |
MTT | MCF-7, HelaS3, CaOV3, B16F10 | Increased values of IC50 were obtained for MCF-7, HelaS3, B16F10 with ChCl:MA, ChCl:Suc, ChCl:Frc, ChCl:Glc, ChCl:gly respectively | [75] |
| 5 | ChCl:Glc ChCl:Frc EAC:TEG |
MTT | HelaS3, PC3, A375, AGS, MCF-7, WRL-68 | 98 ≤ EC50 ≥ 516 mM for ChCl: Glc and ChCl: Frc, 34 ≤ EC50 ≥ 120 mM for EAC: TEG EC50 values ChCl:Glc and ChCl:Frc >> aqueous solutions of ChCl, Frc and Glc |
[76] |
| 6 | 28-based ChCl DESs combined with alcohols, sugars, and derivatives | MTT and QSAR analysis | HEK-293 | IC50 values in the range of 3.52–75.46 mM | [77] |
| 7 | ChCl:AsC | MTS | L929 | EC50 1.47 ± 0.48 mM Above EC50, the cells presented an apoptotic morphology |
[79] |
| 8 | Menthol:SA Menthol:MyA Menthol:LaA |
MTS | HaCaT | EC50 5.569 ± 0.326 mM for menthol:LaA < Menthol:MyA˂ Menthol:SA | [80] |
| 9 | LIM:CpA LIM:Menthol LIM:IBU (1:4) and (1:8) |
MTS | Caco-2 | EC50 10.50 ± 0.883 mM for LIM:IBU (1:4)> LIM:IBU (1:8)˃LIM:menthol˃LIM:CpA LIM:IBU showed potential as a drug delivery system in anti-cancer therapies |
[81] |
| 10 | CA:Ethambutol:H2O (2:1:10) CA:ARG:H2O (1:1.7) to (2:1:9) |
MTS | Caco-2 | IC50 0.1085 for CA:ARG:H2O (1:1:7) comparable to ARG | [83] |