Table 6.
MIC values to cephalosporins and β-lactamase genes of 52 ESBL-producing Shigella isolates from clinical specimens.
| Strain | Antimicrobial pattern | No. isolate | MIC (μg/ml) |
β-lactamase and ESBL gene | |||
|---|---|---|---|---|---|---|---|
| FOX | CTX | CAZ | CRO | ||||
| S. sonnei phase I | CTX-CAZ-CRO-CIP-NAL (n = 1) | 1 | 6 | ≥256 | 192 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 |
| CTX-CAZ-CRO-NAL (n = 5) | 2 | 2 | ≥256 | 64 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 | |
| 1 | 1.5 | 128 | 32 | ≥256 | blaCTX-M-15, blaTEM-1 | ||
| 1 | 3 | ≥256 | 48 | ≥256 | blaCTX-M-15, blaCMY-2 | ||
| 1 | 1.5 | ≥256 | 32 | 192 | blaCTX-M-14, blaTEM-1 | ||
| CTX-CAZ-CRO (n = 6) | 2 | 3 | ≥256 | 48 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 | |
| 1 | 3 | 128 | 32 | ≥256 | blaCTX-M-15, blaTEM-1 | ||
| 1 | 2 | ≥256 | 32 | ≥256 | blaTEM-1, blaCMY-2 | ||
| 1 | 2 | 128 | 32 | ≥256 | blaCTX-M-15, blaTEM-1 | ||
| 1 | 2 | ≥256 | 48 | ≥256 | blaCTX-M-15 | ||
| CTX-CRO-NAL (n = 1) | 1 | 2 | 94 | 16 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 | |
| CTX-CRO (n = 1) | 1 | 2 | ≥256 | 12 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 | |
| S. sonnei phase II | CTX-CAZ-CRO-CIP-NAL (n = 2) | 1 | 6 | ≥256 | ≥256 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 |
| 1 | 6 | ≥256 | 128 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 | ||
| CTX-CAZ-CRO-NAL (n = 20) | 5 | 4 | ≥256 | 48 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 | |
| 1 | 3 | ≥256 | 48 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 | ||
| 1 | 6 | ≥256 | ≥256 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 | ||
| 1 | 4 | ≥256 | 32 | 128 | blaCTX-M-15, blaTEM-1, blaCMY-2 | ||
| 1 | 4 | ≥256 | ≥256 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 | ||
| 1 | 3 | 96 | 32 | ≥256 | blaCTX-M-15, blaTEM-1 | ||
| 1 | 2 | ≥256 | 48 | ≥256 | blaCTX-M-15, blaTEM-1 | ||
| 1 | 2 | 192 | 32 | ≥256 | blaCTX-M-15, blaTEM-1 | ||
| 1 | 3 | ≥256 | 32 | ≥256 | blaCTX-M-15, blaTEM-1 | ||
| 1 | 3 | ≥256 | 64 | ≥256 | blaCTX-M-15, blaCMY-2 | ||
| 1 | 3 | ≥256 | 48 | ≥256 | blaTEM-1, blaCMY-2 | ||
| 1 | 4 | ≥256 | 96 | ≥256 | blaTEM-1, blaCMY-2 | ||
| 3 | 3 | ≥256 | 48 | ≥256 | blaCTX-M-15 | ||
| 1 | 3 | ≥256 | 32 | ≥256 | blaCTX-M-14, blaTEM-1 | ||
| CTX-CAZ-CRO (n = 11) | 1 | 8 | ≥256 | 32 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 | |
| 1 | 6 | ≥256 | 32 | ≥256 | blaCTX-M-15, blaTEM-1 | ||
| 2 | 3 | ≥256 | 32 | ≥256 | blaCTX-M-15, blaTEM-1 | ||
| 1 | 1.5 | ≥256 | 32 | ≥256 | blaCTX-M-15, blaTEM-1 | ||
| 2 | 3 | ≥256 | 32 | ≥256 | blaCTX-M-15, blaTEM-1 | ||
| 1 | 3 | ≥256 | 48 | ≥256 | blaCTX-M-15, blaCMY-2 | ||
| 1 | 3 | ≥256 | 48 | ≥256 | blaCTX-M-15 | ||
| 1 | 4 | ≥256 | 32 | ≥256 | blaCTX-M-14, blaTEM-1, blaCMY-2 | ||
| 1 | 3 | ≥256 | 32 | ≥256 | blaCTX-M-14 | ||
| CTX-CRO-NAL (n = 1) | 1 | 3 | 96 | 24 | ≥256 | blaCTX-M-15, blaTEM-1 | |
| CTX-CRO (n = 2) | 1 | 3 | ≥256 | 24 | ≥256 | blaCTX-M-15, blaTEM-1 | |
| 1 | 3 | ≥256 | 16 | ≥256 | blaCTX-M-15, blaTEM-1, blaCMY-2 | ||
| S. sonnei phase I,II | FOX-CTX-CAZ-CRO-CIP-NAL (n = 1) | 1 | ≥256 | ≥256 | ≥256 | 128 | blaCTX-M-15, blaCMY-2 |
| S. flexneri type 2a | CTX-CRO-NAL (n = 1) | 1 | 6 | 48 | 1.5 | ≥256 | blaCTX-M-15, blaTEM-1 |
CAZ, ceftazidime; CTX, cefotaxime; CRO, ceftriaxone; FOX, cefoxitin, NAL, nalidixic acid and CIP, ciprofloxacin.