Extended Data Fig. 6.

Irreversible inhibition of ODC1 phenocopied exacerbated S. Typhimurium induced cell death from Lacc1^−/− inflammatory BMDMs. a, b, c, ELISA measurements of TNFα, IL6, and IL12b, respectively, secreted by BMDMs stimulated by LPS and IFNγ with or without 1 mM DFMO and/or 500 μM putrescine (Put) treatment. d, CFUs of intracellular S. Typhimurium in inflammatory BMDMs. e, LDH assay in S. Typhimurium infected inflammatory BMDMs. The mean and SEM (error bars) are derived from three biological replicates (n = 3). Statistical significance (two-tailed t-test) compared to control (Ctrl): *P<0.05; **P<0.01; ns, not significant.