Extended Data Fig. 7.

Summary of the enzymatic functions of LACC1 in inflammatory macrophages. a, LACC1’s newly described role in bridging L-Arg and polyamine metabolism in inflammatory macrophages. The carbons are highlighted with consistency to our 1,2,3,4,5-¹³C₅-L-Cit (red) and 6-¹³C₁-L-Cit (blue) feeding studies in inflammatory BMDMs. Carbons in spermidine and spermine highlighted in green derive from dcSAM. b, The involvement of LACC1 (a.k.a., FAMIN) in the purine nucleotide cycle as a purine nucleoside enzyme¹⁸. ADSL, adenylosuccinate lyase; ADSS, adenylosuccinate synthase; AMP, adenosine monophosphate; AMPD, AMP deaminase; GDP, guanosine diphosphate; GMP, guanosine monophosphate; GTP, guanosine triphosphate; IMP, inosine monophosphate; XMP, xanthosine monophosphate.