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(A) An abdominal contrast-enhanced CT image reveals a resistant lesion appearing in the liver with a yellow circle. Histopathologic analysis of biopsy specimen of the resistant lesion on the liver: (B) HE staining of the specimen, (C) strong positive TTF-1 nuclear staining, (D) with PD-L1 tumor proportion score of 0%, and (E) with scarce CD8-positive lymphocytes. CT, computed tomography; HE, hematoxylin and eosin; PD-L1, programmed death-ligand 1.
