Skip to main content
. 2022 Dec 13;26(1):105805. doi: 10.1016/j.isci.2022.105805

Figure 7.

Figure 7

Proposed models showing migration and differentiation of HFSCs to sebocytes in normal and altered conditions

(A) A schematic presentation depicting the progenies of Gli1+ and K15+ HFSCs in the HF and SG during the first hair cycle.

(B) A schematic illustration of the fate of Lgr5+ HFSCs in the second hair cycle. (C) A schematic illustration showing the fate of Lgr5+ and K15+ HFSCs in Lgr5:mTmG and K15:mTmG mice, respectively.

(C and D) A schematic summarizes that wounding to the skin accelerates the differentiation of bulge SCs into SG cells (C), and the process is abolished by β-catenin inhibition (D).

(E and F) Schematic diagrams depicting the activation (E) and inhibition of β-catenin on the differentiation of bulge SCs into SG cells. J-Z, junctional zone; PWD, post-wound day; Derm, dermis; Epi, epidermis; IFE, interfollicular epidermis; IFN: infundibulum; SG: sebaceous gland; W, wound; PSU, the pilosebaceous unit.