REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit anti-CD34(1:50)	Invitrogen	Cat＃MA5-32059; RRID: AB_2809353
SCD-1(1:150)	Cell signaling	Cat＃2794S
Shh Polyclonal antibody(1:200)	Proteintech	Cat＃20697-1-AP; RRID: AB_10694828
Cytokeratin 15 Polyclonal antibody(1:50)	Proteintech	Cat＃10137-1-AP; RRID: AB_2234359
Anti-Gli1 antibody(1:50)	Abcam	Cat＃ab217326
Cytokeratin 15 Polyclonal antibody(1:50)	Proteintech	Cat＃10137-1-AP
Experimental models: Organisms/strains
B6; SJL-Tg(Krt1-15-cre/PGR)22Cot/J(K15-CrePR1)	005249 (Jax mice)	N/A
Gli1tm3(cre/ERT2)Alj/J	007913 (Jax mice)	N/A
Ctnnb1tm1Mmt	(Southern University of Science and Technology)	N/A
B6.129-Ctnnb1tm2Kem/KnwJ	004152(Jax mice )	N/A
Gt(ROSA)26Sortm4(ACTB-tdTomato,EGFP)Luo/J	007576 (Jax mice)	N/A
B6.129S6-Shhtm2(cre/ERT2)Cjt/J	005623 (Jax mice)	N/A
B6.129P2-Lgr5tm1(cre/ERT2)Cle/J	008875 (Jax mice)	N/A
B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J	007909 (Jax mice)	N/A
B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J	006148 (Jax mice)	N/A
Software and algorithms
Prism, Version 8.30	GraphPad	https://www.graphpad.com/scientific-software/prism
NLS Element Viewer 4.50	Nikon	https://www.microscope.healthcare.nikon.com
ZEISS 2.30	Carl Zeiss	https://www.zeiss.com/microscopy/us/products/microscope-software
R 3.62	R	https://www.r-project.org/
Bioconductor	Bioconductor	https://bioconductor.org/packages/
FV1000	Olympus	https://olympus-fv1000-viewer.updatestar.com/
SPSS 26.0	IBM	https://spss.en.softonic.com/