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. 2022 Dec 12;26(1):105799. doi: 10.1016/j.isci.2022.105799

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© 2022.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

CTD connects the dots to identify multigene biomarker panels of response to carboplatin and docetaxel

(A) CTD is a network method that can be used to “connect the dots” and identify highly connected sets of genes. CTD takes a weighted graph and a set of nodes of interest (gray) and outputs a set of highly connected genes (purple) with a p value of connectedness.

(B) Highly connected nodes may be connected through their latent connection to response.

(C) CTD carboplatin epithelial submodule 5, which contains 3 informative genes highlighted with a star.

(D) CTD docetaxel epithelial submodule 23, which contains one informative gene highlighted with a star.

(E) Table of all the informative genes for carboplatin identified with the CTD/WGCNA approach.

(F) Table of all the informative genes for docetaxel identified with the CTD/WGCNA approach.