Fig. 13.

Schematic diagram of PLGA based nanospheres for drug delivery in SCI treatment. (A) The morphology of PLGA nanospheres loaded with MP under SEM, local delivery for dorsal over-hemisection lesioned spinal cord and their in vitro inhibition of inflammation. (B) Showing that SCI lesion range was significantly reduced after the NPs therapy. (A–B) Copyright 2009 Biomaterials [93]. (C) PLGA nanosphere loading flavopiridol to inhibit astrocytes proliferation in vitro. Copyright 2014 Biomaterials [110]. (D) PLGA NPs encapsulating antioxidant enzymes to keep neural cells from apoptosis by attenuating mitochondrial dysfunction. Copyright 2020 Journal of Controlled Release [111].