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Illustration of the structure of nanobubbles and the application in SCI treatment. (A) Showing targeted gene delivery nanobubble under LIFU irradiation. (B) The morphology of nanobubbles and their successful binding to microtubule-associated protein 2, assessed by CLSM. (C) Nanobubble delivery therapy via LIFU-mediation significantly increaseed the expression of BDNF in vivo. Copyright 2018 Biochemical and Biophysical Research Communications [42].
