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. 2023 Jan 5;13:192. doi: 10.1038/s41598-022-26741-7

Table 2.

The proportion of anticoagulant prescriptions by group of stratified cerebral infarction risk and bleeding risk.

Year 2011 2012 2013 2014 2015
Group Af DOAC VKA Total Af DOAC VKA Total Af DOAC VKA Total Af DOAC VKA Total Af DOAC VKA Total
n n (%) n (%) n (%) n n (%) n (%) n (%) n n (%) n (%) n (%) n n (%) n (%) n (%) n n (%) n (%) n (%)
1 345 8 (2.3) 53 (15) 61 (18) 369 18 (4.9) 57 (15) 75 (20) 398 46 (12) 55 (14) 101 (25) 386 68 (18) 38 (9.8) 106 (28) 397 78 (20) 27 (6.8) 105 (26)
2 19 1 (5.3) 6 (32) 7 (37) 20 1 (5.0) 3 (15) 4 (20) 33 2 (6.1) 9 (27) 11 (33) 26 3 (12) 3 (12) 6 (23) 38 6 (16) 3 (7.9) 9 (24)
Total (1 + 2) 364 9 (2.5) 59 (16) 68 (19) 389 19 (4.9) 60 (15) 79 (20) 431 48 (11) 64 (15) 112 (26) 412 71 (17) 41 (10) 112 (27) 434 84 (19) 30 (6.9) 114 (26)
3 4233 146 (3.4) 1254 (30) 1400 (33) 4768 307 (6.4) 1485 (31) 1792 (38) 5079 718 (14) 1404 (28) 2122 (42) 5547 1279 (23) 1265 (23) 2544 (46) 5897 1706 (29) 1169 (20) 2875 (49)
4 3587 184 (5.1) 1738 (49) 1922 (54) 4058 337 (8.3) 1882 (46) 2219 (55) 4610 798 (17) 1898 (41) 2696 (59) 5211 1340 (26) 1895 (36) 3235 (62) 5745 1980 (35) 1792 (31) 3772 (66)
Total (3 + 4) 7820 330 (4.2) 2992 (38) 3322 (43) 8826 644 (7.3) 3367 (38) 4011 (45) 9689 1516 (16) 3302 (34) 4818 (50) 10,758 2619 (24) 3160 (29) 5779 (54) 11,642 3725 (32) 2991 (26) 6716 (58)

Group 1: CHA2DS2-VASc = 1, HAS-BLED = 1, 2; Group 2: CHA2DS2-VASc = 1, HAS-BLED ≧ 3; Group 3: CHA2DS2-VASc ≧ 2, HAS-BLED = 1,2; Group 4: CHA2DS2-VASc ≧ 2, HAS-BLED ≧ 3.

*Af Atrial fibrillation.

VKA Vitamin K antagonist.

DOAC direct oral anticoagulant.

§CHA2DS2-VASc score heart failure, hypertension, age ≥ 75 years (doubled), diabetes mellitus, prior cerebral infarction or TIA (doubled), vascular disease, age 65–74 years, female sex.

||HAS-BLED score hypertension, kidney dysfunction, liver dysfunction, prior cerebral infarction or TIA, prior bleeding or predisposition to bleeding, age ≥ 65 years, use of AP and NSAIDs, alcoholism.

#NSAIDs non-steroidal anti-inflammatory drugs.

**TIA transient ischemic attack.