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. 2021 May 10;4:58. doi: 10.1038/s42004-021-00496-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Single-crystal structures of 4₁₃-helix formed by 11-mer 4, 13-mer 6, and 14-mer 7. The intramolecular hydrogen bond was indicated as orange dashed line in the inset. The nonpolar hydrogens were omitted for clarity. Solvent molecules were also excluded from the crystal lattice. b Two sets of head-to-tail intermolecular hydrogen bonding in the 1:1 + α type of oligomers; c One set of head-to-tail intermolecular hydrogen bonding in the exactly 1:1 ratio type of oligomers. d A comparison of π-helix and 4₁₃-helix. Left: a short seven residue π-helix (orange) embedded within a longer α-helix (green), taken from PDB code 3QHB. Right: a short seven residue fragment of π-helix mimetic (orange), taken from 11-mer 4.