Table 2.

Outcomes for central and extended hepatectomy for hepatocellular carcinoma

Outcomes	Studies (n)	Patients (n)	Effect estimate [RR/MD (95% CI)]	Heterogeneity	Test for overall effect	Favour group
Overall survival
1-year	8	1634	1.00 [0.96, 1.04]	I2 = 16% (P = 0.31)	Z = 0.10 (P = 0.92)	None
2-year	6	855	1.14 [1.06, 1.23]	I2 = 21% (P = 0.27)	Z = 3.46 (P = 0.0005)	CH
3-year	7	1530	1.13 [0.97, 1.33]	I2 = 71% (P = 0.002)	Z = 1.56 (P = 0.12)	None
4-year	5	765	1.31 [1.16, 1.48]	I2 = 6% (P = 0.36)	Z = 4.38 (P < 0.0001)	CH
5-year	7	1565	1.14 [0.96, 1.35]	I2 = 56% (P = 0.03)	Z = 1.54 (P = 0.12)	None
Disease free survival
1-year	8	1605	1.03 [0.92, 1.15]	I2 = 50% (P = 0.05)	Z = 0.49 (P = 0.63)
2-year	5	765	1.04 [0.90, 1.20]	I2 = 29% (P = 0.23)	Z = 0.48 (P = 0.63)
3-year	7	1447	1.19 [0.91, 1.56]	I2 = 74% (P = 0.0007)	Z = 1.26 (P = 0.21)
4-year	5	765	0.92 [0.75, 1.13]	I2 = 37% (P = 0.18)	Z = 0.79 (P = 0.43)
5-year	7	1565	0.81 [0.61, 1.08]	I2 = 60% (P = 0.02)	Z = 1.43 (P = 0.15)
Recurrence	4	1081	1.04 [0.94, 1.15]	I2 = 27% (P = 0.25)	Z = 0.76 (P = 0.45)
Mortality	8	1626	0.55 [0.26, 1.15]	I2 = 0% (P = 0.91)	Z = 1.58 (P = 0.11)
Complications
Overall	7	1270	0.94 [0.76, 1.16]	I2 = 0% (P = 0.48)	Z = 0.57 (P = 0.57)
Liver cell failure	6	1415	0.47 [0.30, 0.76]	I2 = 0% (P = 0.52)	Z = 3.10 (P = 0.002)	CH
Biliary fistula	7	1455	1.90 [1.07, 3.40]	I2 = 0% (P = 0.85)	Z = 2.18 (P = 0.03)	EH
Ascites	4	1084	1.95 [1.00, 3.78]	I2 = 0% (P = 0.88)	Z = 1.97 (P = 0.05)	None
Wound infection	5	1282	0.77 [0.39, 1.52]	I2 = 0% (P = 0.79)	Z = 0.76 (P = 0.44)
Operative details
Time of the operation	4	328	0.82 [0.36, 1.27]	I2 = 57% (P = 0.07)	Z = 3.53 (P = 0.0004)
Blood loss	3	280	40.87 [− 8.81, 90.54]	I2 = 13% (P = 0.32)	Z = 1.61 (P = 0.11)
blood transfusion	3	224	269.54 [− 169.28, 708.35]	I2 = 78% (P = 0.01)	Z = 1.20 (P = 0.23)
Hospital stay	3	280	− 2.17 [− 5.56, 1.22]	I2 = 83% (P = 0.003)	Z = 1.25 (P = 0.21)