Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 5;11:2. doi: 10.1186/s40364-022-00433-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — TP53 in HNSCC cell death. Tumour protein p53 (TP53) acts on mitochondria. MOMP inhibits BCL-2 and BCL-2L1, as antiapoptotic members, and activates BAX, BBC3 (also known as PUMA) and PMAIP1 (also known as NOXA), which are proapoptotic members of the Bcl2 family, thus triggering TP53-dependent apoptosis. P53 can also downregulate the mTOR signalling pathway to promote autophagy. TP53 induces iron death by inhibiting the expression of SLC7A11 or directly acting on diamine acetyltransferase SAT1 and mitochondrial glutaminase GLS2. TP53 inhibits iron death by inhibiting the activities of dipeptidyl peptidase 4 (DPP4) and NADPH oxidase 1 (NOX1) or inducing the expression of cyclin-dependent kinase inhibitor 1 A (CDKN1A). BAK1, BCL-2 homologous antagonist/killer 1; BBC3, BCL-2-binding component 3; CDKN1A, cyclin-dependent kinase inhibitor 1 A; CYCS, cytochrome C, somatic; GLS2, glutaminase 2; GPX4, glutathione peroxidase 4; GSH, glutathione; mTOR, mechanistic target of rapamycin kinase; PMAIP1, phorbol-12–myristate-13 acetate-induced protein 1; ROS, reactive oxygen species; SLC7A11, solute carrier family 7 member 11; SAT1, spermidine/spermine N1-acetyltransferase 1