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. 2022 May 19;5:63. doi: 10.1038/s42004-022-00678-4

Fig. 2. Asymmetric hydrogenation of various N-Boc-β-amino ketones with Ir–(RC,SP,RC)-L6 catalyst.

Fig. 2

Reaction conditions: 0.4 mmol scale, 0.05 mol% [Ir(COD)Cl]2, 0.105 mol% (RC,SP,RC)-L6, 5 mol% NaOtBu, 2.0 mL toluene, room temperature (25–30 °C). Isolated yields. The ee determined by HPLC. aat 60 °C.