Skip to main content
. 2022 Nov 1;128(1):148–159. doi: 10.1038/s41416-022-02032-w

Fig. 2. Sotorasib-resistant cancer cells exhibit enhanced cell–matrix adhesion.

Fig. 2

a Sotorasib-resistant cells have large flat morphology with multiple protrusions. b Rhodamine-phalloidin and vinculin staining showed increased stress fibres and focal adherens in sotorasib-resistant cells. c GSEA showed enrichment of the extracellular matrix–receptor interaction signalling pathway in sotorasib-resistant MIA PaCa-2 cells. d Adhesion assay showed that sotorasib-resistant MIA PaCa-2 cells are more adherent than untreated cells. (n = 5).