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. 2022 Nov 1;128(1):148–159. doi: 10.1038/s41416-022-02032-w

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Fig. 4 — a, c Results of the MTT assay revealed that the combination of the PAK inhibitor FRAX597 and sotorasib exerted stronger cytotoxic effects than did sotorasib alone in cancer cells with KRAS^G12C mutations. b, d Combination treatment of FRAX597 and sotorasib reduced the viability of sotorasib-resistant cells. e–h FRAX486 also showed synergy with sotorasib treatment in treatment-naive cells and sotorasib-resistant cells. ^#CI < 1 at the indicated dose (n = 6 for all experiments).