Fig. 3.

Metabolic connectivity within the limbic CSTC circuits in asymptomatic MAPT mutation carriers. A Connectivity weights in asymptomatic mutation carriers compared with noncarriers. Asymptomatic mutation carriers showed the decreased fronto-striatal connectivity and compensatory increased striato-thalamo and thalamo-cortical connection within limbic CSTC circuits. B Connectomes projected onto a 3D brain template. Enhanced metabolic connections are represented by red lines, and weakened metabolic connections are represented by blue lines. Abbreviations: vmPFC, ventromedial prefrontal cortex; ACC, anterior cingulate cortex