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. 2023 Jan 5;42:5. doi: 10.1186/s13046-022-02562-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Downregulation of KLF14 is correlated with poor prognosis in HCC. A Relative mRNA level of KLF14 in 69 paired tumor tissues and adjacent tissues of HCC. B Expression ratios of “tumor tissues/adjacent tissues” in HCC were calculated and shown as histogram (n = 69). C The protein level of KLF14 in tumor tissues and its matched adjacent tissues. D The protein level of KLF14 in normal liver cells and HCC cell lines. E Representative Immunohistochemistry staining of KLF14 in HCC tumor and adjacent tissues (n = 90) were exhibited (scale bar, 100 μm). F Alteration of KLF14 expression in paired samples are depicted in the pie chart. G-H Kaplan-Meier analyses were conducted to evaluate the overall survival (G) and disease-free survival (H) according to the expression of KLF14 in HCC tissue chip (n = 90). Data are presented as the mean ± SD. Two-tailed unpaired Student’s T-tests were performed. ***P < 0.001