Fig. 7. Pearson correlation between the effective occupancy and pressure for hydrogen bonds or hydrophobic contacts.

a The donors/acceptors of side-chain involved direct H- bonds. b The water-bridged H-bonds. c The water-bridged hydrophobic contacts. For (a, b), the x-axis labels both specific residue and atom involved in the H-bonds, and the ones with underline indicate the H-bonds between side chains and the remainings are between backbone and side chain.