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. 2022 Nov 3;5:143. doi: 10.1038/s42004-022-00761-w

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Proposed mechanism for phosphate mediated peptide formation starting from Ser based on the mechanism for trimetaphosphate mediated amino acid coupling suggested by Rabinowitz et al. (black: m/z value found; red: m/z value not detected; oxidation: ox.)⁸⁰. b Products of the reaction starting from a mixture containing all canonical nucleosides (each 25 mM, in total 1.0 eq.) with H₃PO₃ (3.0 eq.) and urea (1.0 eq.) after 7 d. The reaction mixture was analyzed by CE-MS (blue: detected, grey: not detected, hatched: several nucleoside combinations with identical m/z values are possible and consequently the signal could not be assigned unambiguously to one nucleoside pair).