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. 2020 Jun 26;3:82. doi: 10.1038/s42004-020-0326-x

Fig. 5. Design of fluorogenic probes based on pKcycl prediction.

Fig. 5

a Measured pKcycl of computationally designed derivatives and red and yellow GGT probes based on them. b Fluorescence spectral imaging of mouse models of peritoneal metastases at 5 min post treatment with probes (100 μM, 300 μL). Excitation, 575–605 nm (HMRR), 503–555 nm (HMRY); emission, 645 nm long pass (HMRR), 580 nm long pass (HMRY). Scale bar: 1 cm.