. 2001 Apr;69(4):2190–2197. doi: 10.1128/IAI.69.4.2190-2197.2001

TABLE 1.

CD45RA⁺RO⁺ T lymphocytes preferentially migrate across endothelium

Expt. no.^a	Markers	% of T lymphocytes with indicated phenotype
Expt. no.^a	Markers	Initial population	Migrated across unstimulated HUVEC^b	Migrated across IL-1-treated HUVEC^b ^c	Migrated across B. burgdorferi-treated HUVEC^b ^c
1	CD45RA⁻RO⁺	39.3	43.2	36.4	45.7
	CD45RA⁺RO⁻	36.2	5.1	4.5	5.5
	CD45RA⁺RO⁺	24.0	51.5	59.0	48.6
2	CD45RA⁻RO⁺	38.9	33.0	30.2	25.8
	CD45RA⁺RO⁻	36.2	5.5	3.3	2.8
	CD45RA⁺RO⁺	22.2	60.8	66.3	71.3
3	CD45RA⁻RO⁺	23.9	25.6	31.9	31.4
	CD45RA⁺RO⁻	49.7	9.7	7.7	9.5
	CD45RA⁺RO⁺	17.5	62.4	59.6	58.4

Each experiment was performed with T cells isolated from a different donor.

All migratory populations show a significant depletion of CD45RA⁺RO⁻ T lymphocytes and enrichment for CD45RA⁺RO⁺ T lymphocytes compared to the initial population (P < 0.05).

On average, 2.0 ± 0.4-fold more T lymphocytes traversed stimulated HUVEC than unstimulated endothelium in these experiments.