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. 2020 Nov 13;3:174. doi: 10.1038/s42004-020-00411-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Study outline. b Absolute body weight and food intake of mice during the treatment phase. c Biochemical parameters at termination (12 weeks of treatment) in the treatment groups. Results are the mean ± SEM. ***p < 0.001 vs. vehicle (Dunnett’s test one-factor linear model). d Liver parameters at termination (12 weeks of treatment) in the treatment groups. Results are the mean ± SEM. **p < 0.01, *p < 0.05 vs. vehicle (Dunnett’s test one-factor linear model). Sample sizes: n = 10 for lean chow, n = 15 for obeticholic acid, n = 16 for vehicle and 41.