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. 2020 Nov 13;3:174. doi: 10.1038/s42004-020-00411-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a NAFLD-related scores for the treatment groups. b Pre- and post-treatment lobular inflammation scores for the individual animals in the treatment groups. **p < 0.01, ^#p < 0.1 (paired t test). c Pre- and post-treatment fibrosis scores for the individual animals in the treatment groups. *p < 0.05 (paired t test). d Effect of treatments on liver inflammatory markers. *p < 0.05, ^#p < 0.1 vs. vehicle (two-way ANOVA). e Pre- and post-treatment liver PSR-positive area for the individual animals in the treatment groups. ***p < 0.001 (paired t test). f Effect of treatments on liver fibrosis markers. ***p < 0.001, *p < 0.05, ^#p < 0.1 vs. vehicle (two-way ANOVA). g Representative histology images from pre- and post-treatment biopsies with H&E and PSR staining for the 41 and obeticholic acid treatment groups. Each set of images was taken from biopsies of the same animal. Sample sizes: n = 15 for obeticholic acid, n = 16 for vehicle and 41.