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. 2022 Nov 8;5:146. doi: 10.1038/s42004-022-00765-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Overall βγ didomain structure of Tpn2 (PDB ID 7XKX, blue) aligned with PtmT2 (PDB ID 5BP8, yellow) and Rv3377c (PDB ID 6VPT, pink). The active site pocket of Tpn2 is circled in green. b Hydrophobic residues found in the active site pocket of Tpn2. The σA-weighted difference (mF_o − DF_c) omit map for Tpn2 with a 3σ contour is shown in green mesh. c Proposed binding mode of GGPP in the active site of Tpn2. C14 of GGPP lies 3.2 Å away from the carboxylate side chain of D296. G485, and the corresponding D502 in PtmT2, lie 3.6 Å from C19 of GGPP. Comparisons of the active site pockets of Tpn2 (d), PtmT2 (e), and Rv3377c (f).