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. 2021 May 10;4:59. doi: 10.1038/s42004-021-00501-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Fidaxomicin (cyan), protein (surface representation/gray). Interaction of C3”-OH with H₂O. Limited space around isobutyric ester moiety. b Detailed view on the binding pocket of fidaxomicin’s noviose moiety. C3”-OH points toward an “open space.” C4”-isobutyric ester fits into its pocket. c Detailed view on the interactions of the noviose part to the protein. C2”-OH is blocked by an interaction with Arg412 (blue).