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. 2022 Dec 22;13:1056417. doi: 10.3389/fimmu.2022.1056417

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Copyright © 2022 Houser, Uriarte Huarte, Wallings, Keating, MacPherson, Herrick, Kannarkat, Kelly, Chang, Varvel, Rexach and Tansey

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PGRN deficient mice exhibit altered monocytic and microglial immunophenotypes in the peripheral blood and brain. (A) Ly-6C^hi frequency of Ly-6C⁺ monocytes in peripheral blood, geometric mean fluorescence intensity (GMFI) of (B) MHC-II and (C) CD44 on monocytes in the brain, (D) microglia counts, and (E) GMFI of MHC-II on microglia from aged WT and PGRN KO mice (n=8-10) determined by flow cytometry; two-way ANOVA, genotype effect p < 0.01 for all, Tukey’s post hoc. Histograms show distribution of fluorescence intensity per cell. Letter(s) centered above groups reflect results of post hoc tests. Groups that do not share any letters are significantly different from one another.