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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Sleep Med. 2022 Oct 17;100:558–564. doi: 10.1016/j.sleep.2022.10.006

Table 3.

Stratified associations between sleep parameters and centrum semiovale ePVS burden

Sleep characteristics OR; 95%(CI); p
ApoE ε4 carrier status Age Hypertension status
Non-carriers Carriers <60 years old ≥60 years old Non-hypertensive Hypertensive
Total sleep time, min 0.99
(0.99–1.00)
p=0.043 		1.02
(1.00–1.03)
p=0.037 		1.00
(0.98–1.01)
p=0.755		 1.00
(0.99–1.00)
p=0.297		 0.99
(0.98–1.00)
p=0.069		 1.00
(0.99–1.01)
0.545
Apnea-Hypopnea index, events/hour 1.22
(0.87–1.72)
p=0.253		 0.91
(0.53–1.55)
p=0.726		 0.96
(0.54–1.68)
p=0.878		 1.20
(0.86–1.69)
p=0.285		 1.42
(0.90–2.24)
p=0.136		 0.98
(0.68–1.41)
p=0.895
N1 sleep, min 1.02
(1.00–1.05)
p=0.055		 1.04
(1.00–1.07)
p=0.059		 1.02
(0.98–1.06)
p=0.299		 1.03
(1.01–1.05)
p=0.017 		1.01
(0.98–1.04)
p=0.426		 1.04
(1.01–1.07)
p=0.009
N2 sleep, min 1.00
(0.99–1.00)
p=0.561		 1.01
(1.00–1.02)
p=0.074		 1.00
(0.99–1.01)
p=0.964		 1.00
(0.99–1.01)
p=0.952		 1.00
(0.99–1.01)
p=0.542		 1.00
(1.00–1.01)
p=0.498
N3 sleep, min 0.99
(0.98–1.00)
p=0.107		 0.99
(0.98–1.00)
p=0.182		 1.00
(0.98–1.01)
p=0.645		 0.99
(0.98–1.00)
p=0.050		 0.99
(0.98–1.00)
p=0.127		 0.99
(0.98–1.00)
p=0.241
REM sleep, min 0.99
(0.98–1.00)
p=0.172		 1.02
(1.00–1.05)
p=0.016 		1.01
(0.99–1.03)
p=0.158		 1.00
(0.98–1.01)
p=0.657		 0.99
(0.98–1.01)
p=0.285		 1.01
(0.99–1.02)
p=0.240

Centrum semiovale ePVS rating are scored from grades 1 to 4 (mild to severe) as a 2-level variable: grades 1 and 2 versus 3 and 4. Models were adjusted for age, sex, time interval between PSG, ApoE ε4 carrier status, hypertension, and smoking. ApoE ε4 allele carrier status and hypertension status were removed as covariates when they were the stratifying variable. ePVS, enlarged perivascular spaces; REM, rapid-eye movement.