Box 2.

Switching from another GLP-1RA to OS

For patients tolerating the maximal dose of existing GLP-1RA therapy, initiate OD semaglutide.[79,81,82]

One day (if switching from a OD/BID GLP-1RA therapy) after the last dose (or when GI symptoms have resolved if not tolerating the maximal dose), or

One week (if switching from OW GLP-1RA) after the last dose (or when GI symptoms have resolved if not tolerating the maximal dose)

Initiate at 3 mg OD (initiation dose), increasing to 7 mg OD after 30 days and, if needed, 14 mg OD after a further 30 days (maintenance doses).