Table 3.
Association of Delta vs. pre-Delta and Omicron vs pre-Delta periods of infection with adverse maternal outcomes.
|
Pre-Delta |
Delta |
Omicron |
Delta Vs Pre-Delta |
Omicron Vs Pre-Delta |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
n = 1402 |
n = 262 |
n = 391 |
|||||||||||||||
| n | % | 95%CI | n | % | 95%CI | n | % | 95%CI | Crude RR | 95%CI | adj. RRa | 95%CI | Crude RR | 95%CI | adj. RRb | 95%CI | |
| Severe maternal adverse outcome | 47 | 3.4% | 2.5–4.4 | 17 | 6.5% | 3.8–10.2 | 4 | 1.0% | 0.3–2.6 | 1.9 | 1.1–3.3 | 1.8 | 1.1–3.2 | 0.3 | 0.1–0.8 | 0.3 | 0.1–0.8 |
| ICU admission | 45 | 3.2% | 2.4–4.3 | 13 | 5.0% | 2.7–8.3 | 4 | 1.0% | 0.3–2.6 | – | – | – | – | ||||
| Length of ICU admission >7 days | 12 | 0.9% | 0.4–1.5 | 5 | 1.9% | 0.6–4.4 | 0 | 0.0% | 0.0–0.9 | – | – | – | – | ||||
| High Flow oxygen | 12 | 0.9% | 0.4–1.5 | 3 | 1.1% | 0.2–3.3 | 0 | 0.0% | 0.0–0.9 | – | – | – | – | ||||
| Non-invasive ventilation | 5 | 0.4% | 0.1–0.8 | 3 | 1.1% | 0.2–3.3 | 0 | 0.0% | 0.0–0.9 | – | – | – | – | ||||
| Mechanical ventilation | 14 | 1.0% | 0.5–1.7 | 7 | 2.7% | 1.1–5.4 | 0 | 0.0% | 0.0–0.9 | – | – | - | – | ||||
| Maternal death (any reason) | 4 | 0.3% | 0.1–0.7 | 0 | 0.0% | 0.0–1.4 | 0 | 0.0% | 0.0–0.9 | – | – | – | – | ||||
In bold: 95% CI does not includes 1.
RR: risk ratio, adj. RR: adjusted risk ratio, ICU: intensive care unit.
Adjusted for ethnicity, educational level, BMI >35 kg/m2, drug use, pulmonary, cardiac, neurological and digestive medical history, previous pregnancy with post-partum hemorrhage or other complication, ongoing pregnancy with intrauterine growth restriction, and trimester of infection.
Adjusted for marital status, ethnicity, educational level, BMI >30 kg/m2, nulliparity, history of cesarean section, cardiac, diabetes, and digestive medical history, previous pregnancy with intrauterine growth restriction or preterm birth, current pregnancy with gestational diabetes or placenta praevia, and trimester of infection.