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. 2022 Dec 22;12:1047177. doi: 10.3389/fonc.2022.1047177

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Copyright © 2022 Guo, Lin, Hua and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRIM31 is highly expressed in several types of tumors (The Human Protein Atlas data). The rabbit polyclonal antibody HPA046400 (Sigma Aldrich) was used for the immunohistochemistry assay. The cancer tissues of glioma, melanoma, thyroid gland, pancreatic cancer and liver cancer were strongly cytoplasmic stained. Occasional membranous positivity was observed in colorectal cancer. Urothelial cancer and most kidney cancers were negatively stained. Normal tissues showed weak to strong cytoplasmic positivity with HPA046400 antibody, as presented at the bottom. In glioma, thyroid cancer, liver cancer, colorectal cancer, and pancreatic cancer, the expression of TRIM31 in cancer cell cytoplasm is higher than that in adjacent normal tissues. However, in lung cancer, testis cancer, kidney cancer, and urothelial cancer, the expression of TRIM31 was lower than that in adjacent normal tissues.