Table 1.
Regulatory mechanisms of LINC00324 in cancer.
| Diseases | Assessed cell lines | LINC00324 expression | Effects in vivo | Effects of LINC00324 knockdown in vitro | Regulatory mechanism | Reference |
|---|---|---|---|---|---|---|
| BC | MDA-MB-231, MCF-7 and MCF-10A | down-regulated | Overexpression of LINC00324 reduces tumor volume | cell cycle↑, proliferation↑, colony formation↑, invasion↑, migration↑, and apoptosis↓ | LINC00324/miR-10b-5p/E-cadherin | (22) |
| CRC | SW620, HCT15, SW480 and HCT116 | upregulated | — | proliferation↓, invasion↓, and migration↓ | LINC00324/miRNA-214-3p; cell cycle regulatory pathway | (18) |
| GC | AGS, MGC803, MKN-45, and GES-1 | upregulated | — | proliferation↓, invasion↓, and migration↓ | LINC00324/miR-3200-5p/BCAT1 | (14) |
| SGC7901 and BGC823 | upregulated | Knockdown of LINC00324 reduces tumor volume | proliferation↓, invasion↓, migration↓, and apoptosis↑ | LINC00324/HuR/FAM83B | (15) | |
| HCC | HuH-7 and THLE-3 | upregulated | Knockdown of LINC00324 reduces tumor volume | proliferation↓, invasion↓, migration↓, apoptosis↑, viability↓, and self-renewal↓ | LINC00324/PU.1/FasL | (17) |
| IOT | Hs38.Tand PA-1 | upregulated | — | viability↓, colony formation↓, and apoptosis↑ | LINC00324/miRNA-214-5p/CDK6, CCND1, MDM2, MDM4,;cell cell cycle regulatory pathway | (9) |
| LAC | A549, PC-9, H1650, SPCA1, and H1299 | upregulated | — | proliferation↓, migration↓, invasion↓, and apoptosis↑ | LINC00324/miR-615-5p/AKT1 | (13) |
| 16HBE | ||||||
| NPC | 5-8F, 6-10B, and NP69 | upregulated | Knockdown of LINC00324 reduces tumor volume | proliferation↓, autophagy↓, apoptosis↑, and viability↓ | LINC00324/miR-3164/PAD4;PI3K/AKT pathway | (12) |
| NSCLC | A549, H1299, H460, SK-MES-1, and SPC-A-1 | upregulated | — | proliferation↓, invasion↓, and migration↓ | LINC00324/miR-139-5p/IGF1R | (11) |
| PTC | Nthy-ori 3-1,K1,TPC-1,BCPAP,KTC-1 | upregulated | — | cell cycle↓, proliferation↓, and apoptosis↑ | Notch signaling pathway | (20) |
| B-CPAP, KTC-1, TPC1, K1, Nthy-Ori 3-1, and 293T | upregulated | — | proliferation↓ and invasion↓ | LINC00324/miR-195-5p/TRIM29 | (36) | |
| RB | Y79 and WERI-RB-1 | upregulated | Knockdown of LINC00324 reduces tumor volume | cell cycle↓, proliferation↓, colony formation↓, invasion↓, migration↓, and apoptosis↑ | LINC00324/miR-769-5p/STAT3; Jak/STAT3 signaling pathway | (19) |
| SaOS | hFOB1.19, 143B, MG-63, Saos-2 and HOS | upregulated | — | proliferation↓ and migration↓ | LINC00324/HuR/WDR66 | (16) |
BC, Breast cancer; CRC, Colorectal cancer; GC, Gastric cancer; HCC, Hepatocellular carcinoma; IOT, Immature ovarian teratocarcinoma; LAC, Lung adenocarcinoma; NPC, Nasopharyngeal carcinoma; NSCLC, Non-small cell lung carcinoma; PTC, Papillary thyroid cancer; RB, Retinoblastoma; SaOS, Osteosarcoma;"↑" means increase and "↓" means decrease.