FIGURE 4.

IBP1 classified JVS+UWT affected animals as treatment responders and non-responders. (A) Percentage of affected and unaffected animals in the control group at the post-fluoxetine time point. (B) Percentage distribution of treatment responders and non-responders in the trauma affected group after fluoxetine treatment. Controls (n = 16), trauma affected animals administered fluoxetine (n = 53). (C) Total distance traveled in WAZM by the non-responders was the least while responders and control traveled similar distance [Kruskal–Wallis test (H (3) = 41.51, p < 0.0001); Dunn’s post-hoc comparison p*** < 0.0001]. (D) Time spent in the WAZM closed arms was the highest by the non-responders but responders and controls spent similar time [Kruskal–Wallis test (H (3) = 20.62, p < 0.0001); Dunn’s post-hoc comparison p*** < 0.0001, p* < 0.05)]. (E) Distance traveled in the closed arms was the least by non-responders but responders and controls traversed similar distance [Kruskal–Wallis test (H (3) = 28.11, p < 0.0001); Dunn’s post-hoc comparison p** < 0.01, p*** < 0.0001]. (F) Distance traveled in the open arm of the WAZM was least by the non-responders while responders and controls covered similar distances [Kruskal–Wallis test (H (3) = 27.21, p < 0.0001); Dunn’s post-hoc comparison p*** < 0.00001]. (G) Total time spent freezing in the WAZM was highest amongst the non-responders but responders and controls spent similar time freezing [Kruskal–Wallis test (H (3) = 34.13, p < 0.0001); Dunn’s post-hoc comparison p*** < 0.00001]. (H) Time spent freezing in the EPM was not statistically different between controls, responders and non-responders [Kruskal–Wallis test (H (3) = 3.573, p = ns]. (I) Anxiety index in the EPM was highest in the non-responders while responders and controls had similar anxiety index [Kruskal–Wallis test (H (3) = 11.85, p < 0.01); Dunn’s post-hoc comparison p* < 0.05]. All data represented as mean ± SEM. Controls (n = 16), treatment responders (n = 26), treatment non-responders (n = 27).