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Pharmacophore model of KRASG12D was derived from the interaction of TH-Z835 and active-site amino acids. The ligand TH-Z835 is shown as cyan stick. Orange spheres correspond to aromatic features (F1 and F2: Aro), and purple spheres represent hydrogen-bond donors (F3 and F4: Don). Active-site residues are shown as green sticks. Hydrogen bonds are represented by black dotted lines.
