TABLE 2.
Name | Docking score [kcal/mol] | K d (nM) | IC50 (nM) a |
---|---|---|---|
Hit compound 1 | −11.56 | 0.98 ± .09 | 212.23 |
Hit compound 2 | −11.69 | 0.46 ± .08 | 89.96 |
Hit compound 3 | −11.75 | 0.13 ± .05 | 43.80 |
Hit compound 4 | −11.61 | 0.76 ± .11 | 145.97 |
TH-Z835 | −10.04 | 1.08 ± 0.07 µM | >300 |
IC50 (nM) is the concentration of compound needed to inhibit cell growth by 50% following 72 h cell treatment with hit compounds 1-4 and TH-Z835, respectively.