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. 2022 Dec 16;13:1057376. doi: 10.3389/fendo.2022.1057376

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Copyright © 2022 Han, Lin, Lu, Wang, Tang, Tao, Cai, He and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRF improves glucose intolerance and reverses insulin resistance in mice with polycystic ovarian syndrome (PCOS). (A, B) Oral glucose tolerance test (OGTT, glucose 2 g/kg), (C, D) Insulin tolerance test (ITT, insulin 0.5 U/kg), (E) Plasma fasting glucose level in four groups. (F) Plasma fasting insulin level in four groups. (G) Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), (H) Plasma leptin level. All data were presented as mean ± SEM **P < 0.01, ***P < 0.001, ****P < 0.0001, DA group vs. DT group; ^#P < 0.05, ^##P< 0.01, ^###P < 0.001, ^####P < 0.0001, HA group vs. HT group, ^^^^P < 0.0001, DA group vs. HA group.