. 2023 Jan 5;18(1):e0280058. doi: 10.1371/journal.pone.0280058

Table 3. Pearson correlations between MSAQ individual items, factors, and other questionnaires.

Pearson correlation coefficients between individual and grouped MSAQ items and the other questionnaires are presented in the table for the overall Motion Sifnos Study population, as well as for the placebo and Tradipitant treatment groups. High (r≥0.70) and very high (r>0.90) correlations are bolded.

	Overall			Placebo			Tradipitant
MSAQ Item(s)	MSSS Worst Score	PGI-S Severity Level	MSAQ Total Score	MSSS Worst Score	PGI-S Severity Level	MSAQ Total Score	MSSS Worst Score	PGI-S Severity Level	MSAQ Total Score
Item 1	0.78 ^*	0.83 ^*	0.82 ^*	0.85 ^*	0.86 ^*	0.81 ^*	0.70 ^*	0.81 ^*	0.84 ^*
Sick to Stomach	0.78 ^*	0.83 ^*	0.82 ^*	0.85 ^*	0.86 ^*	0.81 ^*	0.70 ^*	0.81 ^*	0.84 ^*
Item 2	0.53	0.61	0.81 ^*	0.53	0.56	0.77 ^*	0.54	0.69	0.86 ^*
Faint-like	0.53	0.61	0.81 ^*	0.53	0.56	0.77 ^*	0.54	0.69	0.86 ^*
Item 3	0.56	0.56	0.73 ^*	0.61	0.55	0.72 ^*	0.47	0.56	0.73 ^*
Annoyed/Irritated	0.56	0.56	0.73 ^*	0.61	0.55	0.72 ^*	0.47	0.56	0.73 ^*
Item 4	0.56	0.64	0.77 ^*	0.59	0.62	0.74 ^*	0.53	0.68	0.81 ^*
Sweaty	0.56	0.64	0.77 ^*	0.59	0.62	0.74 ^*	0.53	0.68	0.81 ^*
Item 5	0.80 ^*	0.83 ^*	0.85 ^*	0.88 ^*	0.89 ^*	0.85 ^*	0.68	0.76 ^*	0.85 ^*
Queasy	0.80 ^*	0.83 ^*	0.85 ^*	0.88 ^*	0.89 ^*	0.85 ^*	0.68	0.76 ^*	0.85 ^*
Item 6	0.58	0.61	0.86 ^*	0.67	0.63	0.87 ^*	0.49	0.60	0.84 ^*
Lightheaded	0.58	0.61	0.86 ^*	0.67	0.63	0.87 ^*	0.49	0.60	0.84 ^*
Item 7	0.29	0.25	0.50	0.32	0.21	0.47	0.30	0.33	0.55
Drowsy	0.29	0.25	0.50	0.32	0.21	0.47	0.30	0.33	0.55
Item 8	0.60	0.65	0.80 ^*	0.62	0.61	0.79 ^*	0.58	0.70 ^*	0.81 ^*
Clammy/Cold Sweat	0.60	0.65	0.80 ^*	0.62	0.61	0.79 ^*	0.58	0.70 ^*	0.81 ^*
Item 9	0.50	0.55	0.79 ^*	0.55	0.52	0.80 ^*	0.45	0.60	0.79 ^*
Disoriented	0.50	0.55	0.79 ^*	0.55	0.52	0.80 ^*	0.45	0.60	0.79 ^*
Item 10	0.49	0.43	0.65	0.55	0.49	0.71 ^*	0.43	0.37	0.60
Tired/Fatigued	0.49	0.43	0.65	0.55	0.49	0.71 ^*	0.43	0.37	0.60
Item 11	0.85 ^*	0.86 ^*	0.84 ^*	0.93 ^**	0.91 ^**	0.86 ^*	0.75 ^*	0.79 ^*	0.83 ^*
Nauseated	0.85 ^*	0.86 ^*	0.84 ^*	0.93 ^**	0.91 ^**	0.86 ^*	0.75 ^*	0.79 ^*	0.83 ^*
Item 12	0.55	0.53	0.74 ^*	0.55	0.54	0.79 ^*	0.53	0.50	0.68
Hot/Warm	0.55	0.53	0.74 ^*	0.55	0.54	0.79 ^*	0.53	0.50	0.68
Item 13	0.62	0.62	0.83 ^*	0.64	0.58	0.84 ^*	0.61	0.69	0.82 ^*
Dizzy	0.62	0.62	0.83 ^*	0.64	0.58	0.84 ^*	0.61	0.69	0.82 ^*
Item 14	0.60	0.63	0.80 ^*	0.69	0.63	0.86 ^*	0.46	0.63	0.72 ^*
Spinning	0.60	0.63	0.80 ^*	0.69	0.63	0.86 ^*	0.46	0.63	0.72 ^*
Item 15	0.85 ^*	0.86 ^*	0.82 ^*	0.92 ^* ^*	0.90 ^*	0.83 ^*	0.76 ^*	0.83 ^*	0.81 ^*
May Vomit	0.85 ^*	0.86 ^*	0.82 ^*	0.92 ^* ^*	0.90 ^*	0.83 ^*	0.76 ^*	0.83 ^*	0.81 ^*
Item 16	0.74 ^*	0.76 ^*	0.83 ^*	0.83 ^*	0.76 ^*	0.84 ^*	0.62	0.76 ^*	0.83 ^*
Uneasy	0.74 ^*	0.76 ^*	0.83 ^*	0.83 ^*	0.76 ^*	0.84 ^*	0.62	0.76 ^*	0.83 ^*
Gastrointestinal Factor	0.87 ^*	0.90 ^*	0.88 ^*	0.93 ^**	0.92 ^**	0.87 ^*	0.78 ^*	0.86 ^*	0.90 ^**
Central Factor	0.64	0.68	0.92**	0.69	0.66	0.93 ^**	0.58	0.73 ^*	0.92 ^*
Peripheral Factor	0.63	0.67	0.85 ^*	0.64	0.64	0.84 ^*	0.61	0.70 ^*	0.86 ^*
Sopite-Related Factor	0.67	0.65	0.87 ^*	0.75 ^*	0.66	0.88 ^*	0.58	0.65	0.86 ^*
MSAQ Total	0.80 ^*	0.83 ^*	1.00 ^**	0.86 ^*	0.83 ^*	1.00 ^**	0.73 ^*	0.84 ^*	1.00 ^**

* denotes high correlation (r≥0.70)

** denotes very high correlation (r>0.90)