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. 2022 Dec 22;12:1025594. doi: 10.3389/fonc.2022.1025594

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Copyright © 2022 Huang, Xia, Guo, Huang, Wang, Huang, Qin, Leng and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genome-wide CRISPR-cas9 knockout screening identifies 4 genes required for cell proliferation of GIC cell lines. (A-C) In 18 genes greatly downregulated by miR-194, 4 genes, including ATP6V1F, PPP1R14B, SLC7A5 and BTF3L4, were required for cell proliferation in 26 gastric cancer cell lines, 21 hepatology cancer cell lines and 44 colorectal cancer cell lines. (D-F) Gene expression analysis showed that ATP6V1F, PPP1R14B, SLC7A5 and BTF3L4 were overexpressed in gastric cancer (STAD), colorectal cancer (COADREAD) and liver cancer (LIHC). **P < 0.01. ***P < 0.001.