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. 2022 Dec 22;13:955476. doi: 10.3389/fimmu.2022.955476

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Copyright © 2022 Pal, Sharma, Mathew and Jaganathan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alterations in lipid metabolism during cancer progression. In cancer cells, lipogenesis and lipolysis is controlled by the pool of ADP and ATP. In nutrient-rich conditions (ADP, ATP ratio is low); acetyl, CoA is converted to free fatty acids with the help of acetyl, CoA carboxylase and FASN. In nutrient-deprived conditions (ADP, ATP ratio is high), free fatty acids enter the mitochondria with the help of CPT1 and CPT1A and help in energy generation (195, 196). [FASN, Fatty acid synthase; CPT1, Carnitine palmitoyl transferase 1; CPT1A, Carnitine palmitoyl transferase 1A; GLUT, Glucose transporter; PPARγ, peroxisome proliferator activator receptor γ].