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. Author manuscript; available in PMC: 2023 Jan 5.
Published in final edited form as: Cell. 2022 Oct 13;185(21):3857–3876. doi: 10.1016/j.cell.2022.09.023

Figure 1. JAK-STAT Timeline.

Figure 1.

This timeline highlights various milestones in understanding the JAK-STAT pathway since 1984. GAS, gamma activated sequence; IFN, interferon; ISGs, IFN stimulated genes, ISRE, interferon-sensitive response element; SCID, severe combined immune deficiency; KO, knockout; SLE, systemic lupus erythematosus; PK, pseudokinase; MPN, myeloproliferative neoplasms; GOF, gain-of-function; SOCS, suppressor of cytokine signaling; PIAS, protein inhibitor of activated STAT, Tum-l, tumorous lethal.