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. Author manuscript; available in PMC: 2023 Jan 5.
Published in final edited form as: Cell. 2022 Oct 13;185(21):3857–3876. doi: 10.1016/j.cell.2022.09.023

Figure 3. Structure of Janus kinases.

Figure 3.

Structure of activated Janus Kinase dimer (green; PDB 7T6F) complexed with the intracellular domain of matured IFNlR1/IL-10Rb (purple) bound to IFN-l (orange) (PDB 5T5W). Of note, the intracellular portion of the receptor binds JAK1 FERM and SH2 domains through N-terminal Box1 and C-terminal Box2 motifs. The JAK kinase-like or pseudokinase domain promotes dimerization of the cytokine receptor/JAK complex.