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. Author manuscript; available in PMC: 2023 Jan 5.
Published in final edited form as: Cell. 2022 Oct 13;185(21):3857–3876. doi: 10.1016/j.cell.2022.09.023

Figure 6. STAT and chromatin organization.

Figure 6.

STATs bind to DNA at epigenetically marked promoters and enhancers of target genes to regulate transcription. Distinct histone epigenetic marks are observed at promoters (H3K4 trimethylation), enhancers (H3K27 acetylation) and pol II transcribed region (H3K36 trimethylation). As an example, the Ifng locus is depicted, which is regulated by a super enhancer composed by multiple tandem enhancer elements occupied by and enriched for STAT, T-bet, as well as p300, in response to cytokine stimulation. Confocal microscopy (upper left corner) documents signal dependent aggregation of STAT transcriptional nuclear condensates (Zamudio et al., 2019). Super enhancers, transcriptional condensates, and topologically associating domains (TADs) may all converge into a functional unit establishing a physical platform to regulate dynamic transcription of target genes.