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. 2022 Dec 22;13:1043572. doi: 10.3389/fimmu.2022.1043572

Figure 4.

Figure 4

Dimethyl itaconate ameliorates the neuroinflammation in T. gondii infected mice. (A) Schematic timeline for DI treatment on cognitive deficits induced by T. gondii infection in mice. (B) Representative immunofluorescent staining of the Iba-1+ cells in CA1, CA3 and DG of the hippocampus (n = 3). (C) The quantification of Iba-1+ cells number in CA1, CA3 and DG of the hippocampus (n = 3, 10 images per mouse per region, scale bar: 50 μm). (D) The mRNA expression of IL-1β, IL-6 and TNF-α in the hippocampus (n = 3). Con+Veh, control mice with vehicle control treatment; Con+DI, control mice with DI treatment; Tg+Veh, T. gondii infected mice with vehicle control treatment; Tg+DI: T. gondii infected mice with DI treatment. Values are mean ± SEM. *P<0.05 vs. control (Con+Veh). # P < 0.05 vs. T. gondii infected (Tg+Veh).