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. 2022 Dec 22;13:1043572. doi: 10.3389/fimmu.2022.1043572

Figure 5.

Figure 5

Dimethyl itaconate improves the cognitive deficits in T. gondii infected mice. (A) Percentage of time spent with the object in the novel place to total object exploration time and (B) the total object exploration time in the novel location test were recorded. (C) Representative track plots of Con+Veh, Con+DI, Tg+Veh and Tg+DI groups recorded by SMART video tracking system in the testing phase. (D) Percentage of time spent with the novel object to total object exploration time and (E) the total object exploration time in the novel object recognition test were recorded. (F) Representative track plots of Con+Veh, Con+DI, Tg+Veh and Tg+DI groups recorded by SMART video tracking system in the testing phase. (G) Percentage of time spent with the novel arm to total arm exploration time in Y-maze spatial memory test. (H) Representative example of spatial memory in the Y-maze test recorded by SMART video tracking system. Note that the mice in Tg+DI group spent more time exploring the novel arm than the mice infected with T. gondii. (I) The nest score and (J) untorn nestlet weight (amount of untorn nesting material) (n = 10 mice for each group). (K) Representative nesting result of Con+Veh, Con+DI, Tg+Veh and Tg+DI groups. Con+Veh, control mice with vehicle control treatment; Con+DI, control mice with DI treatment; Tg+Veh, T. gondii infected mice with vehicle control treatment; Tg+DI: T. gondii infected mice with DI treatment. Values are mean ± SEM. *P<0.05, **P<0.01, ***P<0.001.