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. 2022 Dec 22;13:1043572. doi: 10.3389/fimmu.2022.1043572
DI dimethyl itaconate
Acod1 aconitate decarboxylase 1
AD Alzheimer’s disease
Tg Toxoplasma gondii
Con control
Veh vehicle
TEM transmission electron microscope
IF immunofluorescence
SYN synaptophysin
PSD95 postsynaptic density 95
SC synaptic cleft
SV synaptic vesicle
Iba1 ionized calcium-binding adaptor molecule1
IL-1β interleukin-1 beta
IL-6 interleukin-6
TNF-α tumor necrosis factor-α
IRG1 immune responsive gene 1
TCA tricarboxylic acid
RNA-seq genome-wide RNA-sequencing
GSEA gene set enrichment analysis
NES normalized enrichment score
SEM standard error of the mean
ANOVA analysis of variance
FDR false discovery rate
NL novel location
NOR novel object recognition
ddH2O double-distilled water
CA1 cornu ammonis 1
CA3 cornu ammonis 3
DG dentate gyrus
PBS phosphate buffered solution
qPCR quantitative real-time PCR
DEGs differential expression genes
GO Gene Ontology
KEGG Kyoto Encyclopedia of Genes and Genomes
P value probability
CC cellular component
MF molecular function
BP biological process
GABA γ-aminobutyric acid
NF-κB nuclear factor kappa-B
JAK-STAT Janus kinase-signal transducer and activator of transcription
Aif1 allograft inflammatory factor 1
Cd86 cluster of differentiation 86
Cd40 cluster of differentiation 40
Ccl2 C-C motif ligand 2
Ccr2 C-C motif chemokine receptor 2
Cx3cr1 C-X3-C motif chemokine receptor 1
Nos2 nitric oxide synthase 2
Sdhaf3 succinate dehydrogenase assembly factor 3
Sucla2 succinate-CoA ligase [ADP-forming] subunit beta
Suclg2 succinate–CoA ligase [GDP-forming] subunit beta
Idh3a isocitrate dehydrogenase 3 catalytic subunit alpha
Mdh2 malate dehydrogenase 2, mitochondrial
Atf3 activating transcription factor 3
Nqo2 N-ribosyldihydronicotinamide: quinone reductase 2
Stat3 signal transducer and activator of transcription 3
Psmb9 proteasome 20S subunit beta 9
Nfe2l2 nuclear factor erythroid-derived 2 like 2
Nrf2 nuclear factor erythroid2-related factor 2
Hk hexokinase
Phi phosphate isomerase
Pfkfb fructose-2,6-biphosphatase
Pfk phosphofructokinase
Aldo aldolase
Gapdh glyceraldehyde-3-phosphate dehydrogenase
Pgk1 phosphoglycerate kinase 1
Pk pyruvate kinase
Pdh pyruvate dehydrogenase complex
Cs citrate synthase
Aco aconitase
Idh isocitrate dehydrogenase
αKGDH α-ketoglutarate dehydrogenase
Sdh succinate dehydrogenase
Fh fumarate hydratase
Mdh malate dehydrogenase
CNS central nervous system
Tnfaip3 (A20) tumor necrosis factor alpha-induced protein 3
Hmox1 heme oxygenase 1
Tap1 transporter 1
LPS lipopolysaccharide