Table 8.

Interactions of apigenin and liquiritin with delta and delta plus variants of SARS-CoV-2

Phytocompound/ drug	Delta			Delta plus
	Binding energy	H-bonding	Hydrophobic interactions	Binding energy	H-bonding	Hydrophobic interactions
Apigenin	− 7	2Arg1012	Thr959, Ala956, Tyr1005, Leu960, Ser1001, Gln963, Thr1004, Gln1008, Gln952, Gln955	− 7.1	-	Thr 959, Gln 1008, Gln 952, Gln 955, Ala 956, Arg 1012, Tyr 1005, Leu 960, Ser 1001, Gln 963, Thr 1004
Liquiritin	− 7.3	5Thr300, Ser50, Asn315, Arg317, Gln626	Cys299, Ala290, Cys289, Glu296, Lys302, Thr628, Thr272, Ser314, Trp631, Gln319	− 7.3	Gln626, Leu627, Ser314, Thr300, Thr272, Ser50	Arg271, Cys299, Ala290, Thr272, Thr628, Pro629, Glu296, Lys302, Cys289