Extended Data Fig. 3. Gain and loss events per functional category across Chlamydiae.

Cladogram of Chlamydiae phylogenetic relationships showing gain (originations and transfers) and loss events of eggNOG NOG gene families with reconciliation frequencies ≥0.3 (see Methods) across COG categories. The barplots mapped onto each branch indicate the events that have occurred leading to the ancestral node to their right. The number of NOGs gained are indicated in the positive direction, and those lost in the negative direction, with the number corresponding to the bar height (see grey box scale). Bars are sorted and coloured according to the COG category. NOGs assigned to poorly characterized COG categories (R: general function prediction only, S: function unknown, X: Mobilome), multiple categories, and de novo gene families were excluded. See Data S7 for gene gains and losses inferred per functional category.