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. 2023 Jan 5;14:77. doi: 10.1038/s41467-022-35727-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Copy number of somatic individual mutations (black and gray points) on chromosome 17 across cohort of TP53-germline mutant tumors. Each black box represents chromosome 17 for one tumor. X-axis for each black box is the position on chromosome 17; Y-axis shows the copy number. Red and green bars are major and minor copy number. Gray points are colored by probability of contributing to SBS1 (clock-like signature). Colored squares at top represent CN state of TP53. CG copy gain. CN copy number. B Number of aging associated mutations (SBS1 or SBS5) occurring before (blue bar) and after (red bar) TP53 CN-LOH. X-axis depicts individual tumors. Y-axis depicts number of aging associated mutations. Source data are provided as a Source Data file.